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Resumen. DELGADO FERNANDEZ, María del Rosario; ROMERO RIVERO, Oscar Luis y DIAZ BORROTO, Abel. Central insipid diabetes: presentation of a case. Articulo en XML; Referencias del artículo; Como citar este artículo; SciELO Analytics; Enviar Neurohypophisis and Insipid Diabetes: A description of a case. Palabras clave: Neurohipófisis [Histología]; Diabetes Insípida [ Diagnóstico];. Existen dos tipos: diabetes insípida (DI) central, debida a la síntesis o liberación defectuosas de arginina vasopresina (AVP) desde el Artículos de referencia.

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Reduction of the expression of aquaporin-2 and of the function of the sodium transporters in the renal tubule: This results in water reabsorption in the collecting duct of the nephron following articulks osmotic gradient. In older children, intense thirst is associated with polyuria with volumes of various liters, and that on occasion is manifested by enuresis, growth dde and anorexia occurs, with preference for intake of cold water.

Once this occurs, the granule membrane is reshaped by the cell after the microvesicles are covered and formed. Important but elusive drug targets. With these urine samples the osmolality and density and the amount of urine will be determined. Acta Neurochir Wien ; Posterior pituitary dysfunction in the form of central diabetes insipidus is rare in patients with Sheehan’s syndrome.

In the former, the patient generally, because of psychological disorders, ingests large quantities of water and other fluids, insipira causes a compensatory polyuria and a clinical picture similar to diabetes insipidus is seen, but without completely affecting the power of renal concentration.

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Sign up for a FREE trial. In particular, aquaporin 2 is regulated by AVP.

Finally, members of some families with the dominant autosomal variant of diabetes insipidus have been studied, in whom mutations of the gene of the aquaporin-2 has also been identified. En el seguimiento de los pacientes con restos tumorales en la RM de control preferimos adoptar una actitud conservadora.


In females who present mutation of the AVPR2the phenotypic expression of the defect could be absent, partially present or complete. Therefore, it is necessary to administer a potassium supplement.

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When the concentration test has revealed a deficiency of the ability of the renal concentration, the AVP response test should be performed. Twenty cases were the standard transsphenoidal approach, and three were endoscopic. Choose one of the access methods below or take a look at our subscribe or free trial options. Currently there is sufficient evidence to continue treatment with hydrochlorothiazide and amiloride 0. On the other hand, different studies have been published in which the effect of the prostaglandin E2 or the related agonists has been investigated such as the EP2 and EP4 prostanoid receptors in experimental animals.

The defect of urine concentration is present from birth so that the clinical manifestations could be observed from the first weeks of life. Zelikovic I, Eisenstein I, editors. Therefore, the episodes of hypernatremic dehydration begin. Figure 2 Urine concentration test in two children with diabetes insipidus.

Localization and functions of AVP. Anatomic changes in the renal medulla are frequently seen in patients with primary tubulointerstitial nephropathies, which modify the osmolar gradient dependent on the action of the mechanisms of the multiplication of the countercur-rent and cause the development of polyuria. However, alterations in the regulation of aquaporin-2 have been observed in patients who receive prolonged treatment with lithium salts for example, treatment of bipolar disorderthe epithelial sodium channel and the urea transporters UT-A1 and UT-Bwith lesion and loss of the main cells of the collecting tubule of the nephron, which can produce an irreversible lesion of the mechanism of urine concentration.

Surgical management of giant pituitary adenomas. It has been suggested that the apparent paradoxical effect of hydrochlorothiazide occurs due to, in the absence of vasopressin arginine, the luminal hydrochlorothiazide increases the osmotic and dilutional permeability of water in the collecting tubules of the nephron that cross the internal renal medulla through independent stimulation of AVP of aquaporin The medial wall of the cavernous sinus: A clinical-radiographic evaluation with computed tomography.


The foregoing precludes progressive weight loss. AVP exercises important effects on the excretion of urine and, with it, on fluid equilibrium. Large pituitary gland adenomas evaluated with magnetic resonance imaging. In addition, she developed Polyuria. Under these conditions, it is advisable to perform a test of urinary concentration, which consists of stimulating the maximum renal concentration in response to water restriction.

This article reviews the causes, clinical manifestations, diagnosis and treatment of patients with nephrogenic diabetes insipidus. Diverse medications affect the renal capacity for concentrating urine and cause variable degrees of polyuria. From functional rescue to promising therapeutic strategies.

Nephrogenic diabetes insipidus | Boletín Médico del Hospital Infantil de México (English Edition)

The variables considered for analysis include invasion and resection grades. The Herbert Olivecrona lecture. Arq Bras Endocrinol Metab [online]. The secondary form is what is observed as part of the clinical picture of different nephropathies Table The entered sign-in details are incorrect.

The condition still continues to be a common cause of hypopituitarism in developing countries like India. For any urgent enquiries please contact our customer services team who are ready to help with any problems.

The journal’s production is being transferred to another wrticulos.